Somatic Cell Hybrids between Mouse Peritoneal Macrophages and Simian-Virus-40-Transformed Human Cells: II. Presence of Human Chromosome 7 Carrying Simian Virus 40 Genome in Cells of Tumors Induced by Hybrid Cells
โ Scribed by Carlo M. Croce, David Aden and Hilary Koprowski
- Book ID
- 123653377
- Publisher
- National Academy of Sciences
- Year
- 1975
- Tongue
- English
- Weight
- 906 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0027-8424
- DOI
- 10.2307/64859
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SV40 DNA sequences have been found in human tumors, such as mesotheliomas, ependymomas, and bone tumors, suggesting that SV40 may be involved in their etiology. The FOS oncogene could play an important role in bone development because SV40 is able to induce FOS in cell culture. In this study, the pr
Cultures of mouse macrophage cell lines transformed by wild-type or the tsA640 mutant of simian virus 40 (SV40) show a reversible phenotypic transition between the nonmacrophage (proliferating phase) and the macrophage (stationary phase) states (Takayama, 1980; Tanigawa et al., 1983). Distribution o