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Somatic cell hybridization studies on the genetic regulation and allelic mutations in metachromatic leukodystrophy

โœ Scribed by Patricia L. Chang; Nadia E. Rosa; Ronald G. Davidson


Book ID
104710351
Publisher
Springer
Year
1982
Tongue
English
Weight
502 KB
Volume
61
Category
Article
ISSN
0340-6717

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Genetic complementation in somatic cell
โœ H. Kihara; Katherine K. Tsay; A. L. Fluharty ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› Springer ๐ŸŒ English โš– 241 KB

Several cases of metachromatic leukodystrophy (MLD) have been described with normal or near normal activities of arylsulfatase A (cerebroside sulfatase). However, the ability of intact cultured fibroblasts to hydrolyze cerebroside sulfate was impaired. Since the impairment was corrected by cerebrosi