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Solvent subset selection for polymorph screening

✍ Scribed by Morten Allesø; Jukka Rantanen; Jaakko Aaltonen; Claus Cornett; Frans van den Berg


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
627 KB
Volume
22
Category
Article
ISSN
0886-9383

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Solvent-mediated polymorphic transformation is an ef®cient technique to obtain the most stable polymorph. The rate of solvent-mediated polymorphic transformation of sulfamerazine at 248C in various solvents and solvent mixtures is controlled by the nucleation rate of the more stable Form II. The tra