Solvent modulation: An accurately modeled method for controlling solute retention in liquid chromatography
✍ Scribed by Wahl, J. H. ;Enke, C. G. ;McGuffin, V. L.
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 351 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0935-6304
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✦ Synopsis
An innovative solvent delivery method termed solvent modulation has been developed to control solute retention in liquid chromatography. Solvent modulation is the technique whereby individual solvent zones are introduced onto the chromatographic column in a known random or repeating sequence. Because the solvent zones are of constant composition and are spatially separated from one another, solute retention is controlled independently in each zone. Hence, the overall retention of a solute is a time-weighted average of the capacity factors in the solvent zones it has encountered. Solvent modulation offers a simple, versatile, and accurately modeled means to control and predict solute retention in liquid chromatography.