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Solvent-Free Synthesis of Quinazoline-2,4(1H,3H)-diones Using Carbon Dioxide and a Catalytic Amount of DBU.

โœ Scribed by Takumi Mizuno; Masatoshi Mihara; Takeo Nakai; Toshiyuki Iwai; Takatoshi Ito


Publisher
John Wiley and Sons
Year
2007
Weight
20 KB
Volume
38
Category
Article
ISSN
0931-7597

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A facile synthesis of substituted 3-amin
โœ Tuan P. Tran; Edmund L. Ellsworth; Brian M. Watson; Joseph P. Sanchez; H. D. Hol ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 124 KB

A new synthesis of a series of 3-amino-1H-quinazoline-2,4-diones is described. The 1H-quinazoline-2,4dione 10 was made starting with fluorobenzoic acid in three high yielding steps. The key step of this synthesis involved the generation of the dianion of urea 7 and the subsequent intramolecular nucl