Solvent free synthesis of acetyl salicylic acid over nano-crystalline sulfated zirconia solid acid catalyst

✍ Scribed by Beena Tyagi; Manish Kumar Mishra; Raksh Vir Jasra

• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 307 KB
• Volume: 317
• Category: Article
• ISSN: 1381-1169
• DOI: 10.1016/j.molcata.2009.10.019

✦ Synopsis

Acetyl salicylic acid, commonly known as Aspirin or Ecotrin, has been synthesized by an eco-friendly route using solid acid catalysts namely nano-crystalline sulfated zirconia, sulfated titania, zeolite H-beta, H-Y, H-ZSM-5 and acid treated K-10 clay. Among all the solid acid catalysts studied, nano-crystalline sulfated zirconia showed highest catalytic activity and was found to be efficient in minimal amount to obtain excellent yield (95 wt%) of acetyl salicylic acid crystals. Thermally regenerated catalyst showed similar yield as obtained with the fresh catalyst.