✦ LIBER ✦
Solvent-Free Solid Acid-Catalyzed Electrophilic Annelations: A New Green Approach for the Synthesis of Substituted Five-Membered N-Heterocycles
✍ Scribed by Mohammed Abid; Andrew Spaeth; Béla Török
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 99 KB
- Volume
- 348
- Category
- Article
- ISSN
- 1615-4150
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
An effective microwave‐induced, solid acid‐catalyzed, environmentally benign synthesis of substituted pyrroles, indoles and carbazoles under solvent‐free conditions is described. The new synthetic methodology is based on the use of a considerably strong solid acid, K‐10 montmorillonite. Both the cyclialkylation of amines and annelation of pyrroles and indoles have been completed within minutes and provided excellent (75–98 %) yields with practically 100 % selectivity.