Solvent-free optical resolution of N-methylamphetamine by distillation after partial diastereoisomeric salt formation

Optical resolution of N-methylamphetamin

Optical resolution of N-methylamphetamine via diastereoisomeric salt formation with 2R,3R-O,O′-di-p-toluoyltartaric acid

✍ Dávid Kozma; Zoltán Madarász; Csaba Kassai; Elemér Fogassy 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 57 KB 👁 2 views

Racemic N-methylamphetamine can be resolved by O,OЈ-di-ptoluoyltartaric acid in methanol either by the classic Pasteurian method by fractional crystallization of the neutral diastereoisomeric salt pair (molar ratio of the base:acid 2:1) or by the Marckwald or the Pope-Peachey method by fractional cr