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Solvent-free one-pot reactions for annulating a pyrimidine ring on thiazoles under microwave irradiation

✍ Scribed by Lal Dhar S Yadav; Suman Dubey; Beerendra S Yadav

Book ID: 104205492
Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 150 KB
Volume: 59
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(03)00854-8

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✦ Synopsis

One-pot reactions of glycine, acetic anhydride and thiazole Schiff bases (2a -f) diastereoselectively and expeditiously annulate a pyrimidine ring on the thiazole nucleus to yield 6,7-dihydro-5H-thiazolo[3,2-a]pyrimidin-5-ones (4a -f) under microwave irradiation and solvent-free conditions.

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