Solvent-Free Microwave Michael Addition Between EMME (I) and Various Nucleophiles.
โ Scribed by Andre Loupy; Suk Jin Song; Seong Jin Cho; Dong Kyu Park; Tae Woo Kwon
- Book ID
- 101977726
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 22 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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๐ SIMILAR VOLUMES
## Abstract Silicon-based thiourea (SiliaBondยฎ Thiourea) (Si-THU), a heterogeneous catalyst, has been applied to the highly selective C-S bond formation via Michael addition of thiols to ฮฑ,ฮฒ-unsaturated carbonyl compounds under solvent-free conditions at 55โ60ยฐC. The thio-Michael addition products
## Abstract The title reaction has the following reaction order: I
## Abstract The general and rapid method avoids strong alkaline nucleophiles and the need for efficient leaving groups.
## Abstract Microwave irradiation is successfully utilized for the first time for activation of unmodified hydrotalcites in Michael addition reactions.