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Solvent effects on the spectrokinetic studies on the molecular complexes of dextromethorphan and atenolol drugs with DDQ

✍ Scribed by M. Pandeeswaran; K. P. Elango

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
521 KB
Volume
40
Category
Article
ISSN
0538-8066

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✦ Synopsis

Abstract

The kinetics and mechanism of the interaction between 2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone (DDQ) and dextromethorphan and atenolol drugs has been investigated spectroscopically. In the presence of large excess of donor drug, the 1:1 charge transfer (CT) complex is transformed into a final product, which has been isolated and characterized by using FT‐IR and GC‐MS techniques. The rate of formation of product has been measured as a function of time in different solvents at three temperatures. The thermodynamic parameters, viz. activation energy, enthalpy, entropy, and free energy of activation were computed from temperature dependence of rate constants. On the basis of the spectrokinetic results, a plausible mechanism for the formation of the CT complex and its transformation into final product is presented and discussed. Cyclic voltammetric study supports the observed solvent effect on the extent of CT complexation and the rate with which it is converted into the product. © 2008 Wiley Periodicals, Inc. Int J Chem Kinet 40: 559–568, 2008

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