Solution Study of the NF-κB p50–DNA Complex by UV Laser Protein–DNA Cross-linking

Distamycin A affects the stability of NF

Distamycin A affects the stability of NF-κB p50-DNA complexes in a sequence-dependent manner

✍ Robert E. Speight; Darren J. Hart; Jonathan M. Blackburn 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 155 KB

## Abstract The effect of two different DNA minor groove binding molecules, Hoechst 33258 and distamycin A, on the binding kinetics of NF‐κB p50 to three different specific DNA sequences was studied at various salt concentrations. Distamycin A was shown to significantly increase the dissociation ra