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Solution structure of β2-microglobulin and insights into fibrillogenesis

✍ Scribed by Gennaro Esposito; Alessandra Corazza; Paolo Viglino; Giuliana Verdone; Fabio Pettirossi; Federico Fogolari; Ads Makek; Sofia Giorgetti; Palma Mangione; Monica Stoppini; Vittorio Bellotti


Book ID
103823320
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
344 KB
Volume
1753
Category
Article
ISSN
1570-9639

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## Abstract Human __β__‐2‐microglobulin (__β__2m) is the light chain of human leucocyte antigen‐I (HLA‐I). It can disassociate from HLA‐I and accumulate to cause serious dialysis‐related amyloidosis (DRA) in long‐term hemodialysis patients. Monoclonal antibody (mAb) BBM.1 can recognize both free‐fo