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Solution Structure of the FK506-Binding Domain of Human FKBP38

✍ Scribed by Mitcheell Maestre-Martínez; Frank Edlich; Franziska Jarczowski; Matthias Weiwad; Gunter Fischer; Christian Lücke

Publisher: Springer Netherlands
Year: 2006
Tongue: English
Weight: 291 KB
Volume: 34
Category: Article
ISSN: 0925-2738
DOI: 10.1007/s10858-006-0018-6

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## Background The pharmacological action of specific immunosuppressants is mediated by immunophilins. While cyclosporin A binds to cyclophilins, FK506/tacrolimus, rapamycin, and others bind to FK506 binding proteins (FKBPs). Different physiological actions of immunophilins were described but their