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Solution structure of a DNA double helix with consecutive metal-mediated base pairs

✍ Scribed by Johannsen, Silke; Megger, Nicole; Böhme, Dominik; Sigel, Roland K. O.; Müller, Jens

Book ID
109912912
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
765 KB
Volume
2
Category
Article
ISSN
1755-4330

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Solution Structure of a Hexitol Nucleic
Solution Structure of a Hexitol Nucleic Acid Duplex with Four Consecutive T⋅T Base Pairs
✍ Eveline Lescrinier; Robert M. Esnouf; Jan Schraml; Roger Busson; Piet Herdewijn 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 German ⚖ 717 KB

The structure of the hexitol nucleic acid (HNA) h(GCGCTTTTGCGC) was determined by NMR spectroscopy. This unnatural nucleic acid was developed as a mimic for A-RNA. In solution, the studied sequence is forming a symmetric double-stranded structure with four central consecutive T ´T wobble pairs flank