𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Solution structure by nuclear magnetic resonance of the two lantibiotics 97518 and NAI-107

✍ Scribed by Francesca Vasile; Donatella Potenza; Barbara Marsiglia; Sonia Maffioli; Stefano Donadio

Book ID
105360049
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
231 KB
Volume
18
Category
Article
ISSN
1075-2617

No coin nor oath required. For personal study only.

✦ Synopsis

Lantibiotics 97518 and NAI‐107, produced by the related genera Planomonospora and Microbispora respectively, are members of a family of nisin‐related compounds. They represent promising compounds to treat infections caused by multiresistant Gram‐positive pathogens. Despite their similar structure and a similar antibacterial spectrum, the two lantibiotics exhibit significant differences in their potency. To gain an insight into the structure–activity relationships, their conformational properties in solution are determined by NMR. After carrying out an NOE analysis of 2D ^1^H NMR spectra, high‐resolution 3D structures are determined using molecular dynamics simulations. Copyright © 2011 European Peptide Society and John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Determination of three-dimensional struc
Determination of three-dimensional structure of nervosin in solution by two-dimensional nuclear magnetic resonance spectroscopy
✍ Yanwu Yang; Xiaolong Xu; Dehua Wang; Baogong Qian 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 490 KB 👁 1 views

## Abstract Two‐dimensional NMR techniques were used to obtain a complete proton spectral assignment of nervosin, a natural product with medicinal interest isolated from a Chinese herbal medicine. The full relaxation matrix analysis method was used to process the NOE matrix of nervosin. The three‐d