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Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of ras (KSR)

✍ Scribed by Ming Zhou; David A Horita; David S Waugh; R.Andrew Byrd; Deborah K Morrison


Book ID
115631556
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
528 KB
Volume
315
Category
Article
ISSN
0022-2836

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The first cysteine-rich domains (CRD's) of mouse PKCq and PKC/~ (~I-CRDI and 6-CRD1) were prepared by automated solid phase peptide synthesis. In the presence of phosphatidylsenne, zinc-folded ~I-CRD 1 did not bind [-SH]phorlx)l 12,13-dibutyrate (PDBu) at all while the zinc-folded second CRD of mous