Solution phase synthesis of a spiro[pyrrolidine-2,3′-oxindole] library via a three component 1,3-dipolar cycloaddition reaction
✍ Scribed by Demosthenes Fokas; William J. Ryan; David S. Casebier; David L. Coffen
- Book ID
- 108386616
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 312 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
## Abstract Regio‐ and stereospecific syntheses of several spiro[pyrrolidine2,3′‐oxindole] derivatives by cycloaddition trapping of azomethine ylides generated in situ, via decarboxylative condensation of isatin with α‐amino acids or by reaction of secondary amines with isatin, are reported. 2,6‐Di
## Abstract The 1,3‐dipolar cycloaddition of an azomethine ylide generated by a decarboxylative route from sarcosine and isatin to 7‐arylmethylidene‐3‐aryl‐3,4‐dihydro‐2__H__‐thiazolo[3,2‐__a__][1,3,5]triazin‐6(7H)‐ones afforded novel dispiro[oxindole‐pyrrolidine]‐thiazolo[3,2‐__a__][1,3,5]triazine