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Solution phase synthesis of (1→5)-amide linked sugar amino acid dimers derived from sialic acids

✍ Scribed by Jacquelyn Gervay; Terrence M. Flaherty; Can Nguyen


Book ID
104256511
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
234 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis


Carboxy-protected amino derivatives and amino-protected carboxy derivatives of three different C-2 analogs as well as a 2,3-dehydro NeuAc were prepared. These monomers were coupled in solution using BOP activation of the carboxy terminus to form (l~5)-amide linked dimers of sialyl amino acid derivatives.


📜 SIMILAR VOLUMES


ChemInform Abstract: Solution Phase Synt
✍ J. GERVAY; T. M. FLAHERTY; NGUYEN CAN NGUYEN CAN 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 2 views

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ChemInform Abstract: Solution Phase Synt
✍ P. S. RAMAMOORTHY; J. GERVAY 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 38 KB 👁 2 views

Solution Phase Synthesis of Amide-Linked N-Acetyl Neuraminic Acid, α-Amino Acid, and Sugar Amino Acid Conjugates. -It is shown that NeuAc can be efficiently conjugated to naturally occurring α-amino acids and subsequently to sugar amino acids yielding diverse compounds with potential biological act

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The parallel iterative solution-phase synthesis of 5-amino-1-aryl- [1,2,4]triazolo [1,5-a]pyridine-7-carboxylic acid amide derivatives is described. The key intermediate 2,6-bis-aminopyridine-4-carboxylic acid methyl ester was synthesised in a two step procedure in 64% overall yield and elaborated t