## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
Solution phase synthesis of (1→5)-amide linked sugar amino acid dimers derived from sialic acids
✍ Scribed by Jacquelyn Gervay; Terrence M. Flaherty; Can Nguyen
- Book ID
- 104256511
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 234 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Carboxy-protected amino derivatives and amino-protected carboxy derivatives of three different C-2 analogs as well as a 2,3-dehydro NeuAc were prepared. These monomers were coupled in solution using BOP activation of the carboxy terminus to form (l~5)-amide linked dimers of sialyl amino acid derivatives.
📜 SIMILAR VOLUMES
Solution Phase Synthesis of Amide-Linked N-Acetyl Neuraminic Acid, α-Amino Acid, and Sugar Amino Acid Conjugates. -It is shown that NeuAc can be efficiently conjugated to naturally occurring α-amino acids and subsequently to sugar amino acids yielding diverse compounds with potential biological act
## Abstract For Abstract see ChemInform Abstract in Full Text.
The parallel iterative solution-phase synthesis of 5-amino-1-aryl- [1,2,4]triazolo [1,5-a]pyridine-7-carboxylic acid amide derivatives is described. The key intermediate 2,6-bis-aminopyridine-4-carboxylic acid methyl ester was synthesised in a two step procedure in 64% overall yield and elaborated t