Solution-mediated effect of bioactive glass in poly (lactic-co-glycolic acid)–bioactive glass composites on osteogenesis of marrow stromal cells
✍ Scribed by Jun Yao; Shula Radin; Gwendolen Reilly; Phoebe S. Leboy; Paul Ducheyne
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 451 KB
- Volume
- 75A
- Category
- Article
- ISSN
- 1549-3296
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✦ Synopsis
Abstract
A previous study demonstrated that the incorporation of bioactive glass (BG) into poly (lactic‐co‐glycolic acid) (PLGA) can promote the osteoblastic differentiation of marrow stromal cells (MSCs) on PLGA by promoting the formation of a calcium–phosphate‐rich layer on its surface. To further understand the mechanisms underlying the osteogenic effect of PLGA‐BG composite scaffolds, whether solution‐mediated factors derived from composite scaffolds/hybrids can promote osteogenesis of marrow stromal cells was tested. The dissolution product from PLGA‐30%BG scaffold stimulated osteogenesis of MSCs, as was confirmed by increased mRNA expression of osteoblastic markers such as osteocalcin (OCN), alkaline phosphatase (ALP), and bone sialoprotein (BSP). The three‐dimensional structure of the scaffolds may contribute to the production of cell‐derived factors that promoted distant MSC differentiation. Thus PLGA‐BG composites demonstrate significant potential as a bone‐replacement material. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2005