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Solution coordination chemistry of protohaemin IX peptide derivatives

✍ Scribed by Elena A. Rozhkova; Rima P. Evstigneeva; Victor N. Nemykin

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
221 KB
Volume
03
Category
Article
ISSN
1088-4246

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✦ Synopsis

As part of an investigation aimed at developing artificial models for mimicking haemoprotein activity, four C-aminoacyl protohaemin IX derivatives with one or two -L-Leu-L-HisOMe (complexes 3 and 1) or -b-Ala-L-HisOMe (complexes 4 and 2) peptide fragments have been studied by means of electronic and ESR spectroscopy. The bis-His complexes 1 and 2 are predominantly low-spin (S = 1/2) species, while the mono-His complexes 3 and 4 are predominantly high-spin (S = 5/2) species. Products of the treatment of starting complexes 1-4 with trichloroacetic acid, acetic acid, methylimidazole, sodium cyanide and sodium hydroxide have been analysed by electronic spectroscopy. Weak-field ligands lead to predominantly high-spin hexacoordinated complexes, while strong-field ligands result in predominantly low-spin ones.

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## Abstract A facile method for the preparation of N1‐ (**1a–6a**) and N3‐alkylated (**1b–6b**) 4‐azabenzimidazole derivatives is presented. Both isomers were obtained by alkylation of 4‐azabenzimidazole. The isomers were separated, and the preferred formation of the N1‐alkylated derivatives (**1a–