Solution conformations of the 6α and 6β epimers of oxymorphamine
✍ Scribed by Ronald C. Crouch; Ashok V. Bhatia; O.William Lever Jr.
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- French
- Weight
- 213 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0040-4039
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The C20 configuration and solution conformation of each epimer of dihydrodigoxigenin has been studied by circular dichroism (CD) and NMR spectroscopy. Results from the CD spectra indicate that the two epimers have opposite orientations of the beta-carbon in the lactone ring. This finding, together w
## Abstract On the basis of NMR spectra of __trans__‐ and __cis__‐2‐alkoxy‐5,6‐α‐pyran‐6‐carboxylic esters it was found that, at room temperature, the __trans__‐compounds exist exclusively in the conformation with equatorial carbalkoxy and pseudoaxial alkoxy groups. The __cis__‐isomers appear to be