Solution conformational analysis of sodium complexed [Gly6]. - and [Gly9]. -antamanide analogs
β Scribed by AMODEO, PIETRO ;SAVIANO, GABRIELLA ;BORIN, GIANFRANCO ;CALDERAN, ANDREA ;RUZZA, PAOLO ;TANCREDI, TEODORICO
- Book ID
- 110893687
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 768 KB
- Volume
- 51
- Category
- Article
- ISSN
- 1397-002X
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A series of sequential polypeptides (Lys,Rj), (R is Leu, Ser, or Gly) and random copolypeptides, (Lys', Leuy), , were synthesized. Their conformation in NaDodS04 solution was determined by CD. Only (Lys-Leu),, (Lys-Ser),, and (Lysa-Ser), adopt a stable 0-form in the surfactant solution; (Lys-Sern),,
The conformational behavior of a heterodetic bicyclic decapeptide (BCPLT) in the absence and in the presence of calcium ions has been studied by means of mono and two-dimensional nmr techniques. Free BCPLT possessee a quite compact structure stabilized by intramolecular bonds and turns. In the struc
## Abstract The cyclic peptide cyclo[βLβProβLβLeuβDβ(Gln)Thzβ(Gly)ThzβLβValβ] (1a), which is a diastereomer of the antineoplastic agent dolastatin 3 (1b), and contains the unusual thiazole amino acids, was synthesized. All the peptide bonds of the cyclic peptide 1a are __trans__ in solution, and th
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