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Solution conformation of lasalocid and lasalocid-Na+ (X-537A)

โœ Scribed by Marc J.O. Anteunis


Book ID
103482600
Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
750 KB
Volume
5
Category
Article
ISSN
0045-2068

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A method is described for the chemical analysis of lasalocid, formerly known as antibiotic X-537A. The method is based on quantitative thermolysis of the antibiotic to a retroaldol ketone which is assayed by gas chromatography. No catalyst or special pyrolysis attachment is needed for the assay, as

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## Abstract Although the covalent structure of Lysocellin (1) differs from Lasalocid (2) at both ends of the molecule, nevertheless the atomic coordinates are such that common ligands [0^ฮธ^ โ€1, OHโ€5, C=0โ€6 and OHโ€10 in 1] lie in a square planar arrangement around the trapped central metal cation. W