โ Scribed by J.C. Montet; M. Lindheimer; N. Kamenka; A.M. Montet
No coin nor oath required. For personal study only.
A series of bile salt solutions were investigated in order to determine the hydrophilic-hydrophobic balance of individual btle salts. Potenttometrtc tttratton, cholesterol and bile acrd solubilizatlon and surface tension were employed Hydrophtlicity greatly depended on the number, positton and orientation of hydroxyl groups. It decreased as follows b muricholate (3r.6fi.78 triOH) > ursodeoxycholate (3a,7fl dtOH) > hyocholate (3n,6r,7r triOH) z hyodeoxycholate (3~6% drOH)>chenodeoxycholate (3~7% dlOH). Taurochenodeoxycholate. tauroursodeoxycholate and /j muricholate were infused m bile fistula rats to evaluate their acute effects on liver and btle secretion Taurochenodeoxycholate infusion led to severe cholestasis. In contrast. the hydrophthc species tauroursodeoxycholate and [I murtcholate were hypercholeretic,
were not hepatotoxtc and were able to protect the liver against the cytotoxtcity of the hydrophobtc bile salt. Ursodeoxychohc acid was also found to be hepatoprotecttve when given for 1 year to patients suffering from cystic fibrosis and hepatopathy It improved standard liver functron tests by decreasing both cholestasrs and cytolysrs.
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