Solution and Solid-Phase Chemoselective Synthesis of (1-6)-Amino(methoxy) Di- and Trisaccharide Analogues.
โ Scribed by Francesco Peri; Alexander Deutman; Barbara La Ferla; Francesco Nicotra
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 32 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0931-7597
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## Abstract __N__โ[1โ(4โ(4โfluorophenyl)โ2,6โdioxocyclohexylidene)ethyl] (Fde) protected amino acids have been prepared and applied in solidโphase peptide synthesis monitored by gelโphase ^19^F NMR spectroscopy. The Fde protective group could be cleaved with 2% hydrazine or 5% hydroxylamine solutio
0 (6R,7R)-7-[2-(5-Amir1o-l,2,4-thiadiazol9-yl)-(Z)-2-methoxyiminoacetamid]-3-[(4-carbamoyl-1 -quinuclidinio)methylJ-8-oxo-5thia-1 -azabicyclo [4,2,0]oct-2-ene-2-carboxylate (1 ; E l 040) was isolated as a-(decahydralte), p-(pentahydrate), and yform (anhydrate) crystals and the X-ray amorphous form.