𝔖 Bobbio Scriptorium
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Solute enhanced partition analysis—A novel method for measuring the binding of drugs to DNA

✍ Scribed by Thomas R. Krugh; Stephen A. Winkle; David E. Graves


Book ID
118316044
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
448 KB
Volume
98
Category
Article
ISSN
0006-291X

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A novel probe was developed to measure drug association with the F1\*S variant of the human serum protein alpha 1-acid glycoprotein (AGP). The molecule 2hydroxy-3,5-diiodo-N-[2(diethylamino)ethyl]benzamide (DEDIC) binds to AGP, quenching its native ¯uorescence. This quenching was ®tted to a two-site