✦ LIBER ✦

Soluble synthetic polymers as targetable agents for intracellular drug release

✍ Scribed by Lloyd, John B. ;Duncan, Ruth ;Pratten, Margaret K.

Book ID: 104527225
Publisher: Wiley (John Wiley & Sons)
Year: 1983
Tongue: English
Weight: 210 KB
Volume: 15
Category: Article
ISSN: 0007-1641
DOI: 10.1002/pi.4980150403

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Soluble synthetic polymers have potential as targetable drug delivery and release agents. Copolymers of 2‐hydroxypropylmethacrylamide with oligopeptide side‐chains have been used to demonstrate the attachment of drug analogues by covalent linkages susceptible to hydrolysis by lysosomal enzymes but stable in plasma. Targeting of polymers to particular sites has been illustrated by making use of the substrate specificity of adsorptive pinocytosis.

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