Soluble Self-Assembled Block Copolymers for Drug Delivery
β Scribed by Glen S. Kwon; Teruo Okano
- Book ID
- 110308438
- Publisher
- Springer US
- Year
- 1999
- Tongue
- English
- Weight
- 682 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0724-8741
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π SIMILAR VOLUMES
Amphiphilic block copolymers (ABCs) have been used extensively in pharmaceutical applications ranging from sustained-release technologies to gene delivery. The utility of ABCs for delivery of therapeutic agents results from their unique chemical composition, which is characterized by a hydrophilic b
## Abstract A series of amphiphilic poly(Lβleucine)β__block__βpoly(ethylene glycol)β__block__βpoly(Lβleucine) (PLLβPEGβPLL) hybrid triblock copolymers have been synthesized. All the blocks in this system have good biocompatibility and low toxicity. The PLLβPEGβPLL copolymers could selfβassemble int
The CMCs of ABCs are typically on the order of 10 Γ6 -10 Γ7 M, 5,6 whereas those of low-molecular-weight surfactants are on the order of 10 Γ3 -10 Γ4 M. 7,8