Enhancement of human IL-4 activity by so
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Thomas Jung; Kathrin Wagner; Christine Neumann; Christoph H. Heusser
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Article
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1999
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John Wiley and Sons
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English
β 153 KB
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The recombinant form of the extracellular domain of the IL-4 receptor (sIL-4R) is a potential candidate to neutralize IL-4; however, murine sIL-4R displayed both antagonistic and agonistic activity in vivo. Here we show that human recombinant sIL-4R induced the formation of complexed IL-4 in superna