โ Scribed by R. Dummer; F. G. Dunkel; H. Takematsu
No coin nor oath required. For personal study only.
Dear Sir, in a recently published paper in this journal, Takematsu and Tagami [2] reported elevated soluble interleukin-2 receptor (sIL-2R) levels in suction blister fluids from psoriatic skin. Although there was no interleukin-2 or interferon-gamma detection, local T-cell activation was suggested based on these data.
We would like to critically examine this assumption. The lack of a determination of sIL-2R in the serum of the patients leaves open the possibility that the sIL-2R levels detected are the result of filtered and diluted serum which contains sIL-2R levels between 280 and 500 U/ml (mean, 429; standard deviation, 75, n = 10) in healthy control patients and elevated sIL-2R levels in psoriatic patients [mean, 830; standard deviation 429, n = 23 (our unpublished results); data obtained with a ELISA provided by T Cell Science, Cambridge, USA]. The slight increase of suction blister sIL-2R from involved skin compared with uninvolved skin from the same individual, might be due to an augmented blood flow in inflamed psoriatic areas. We also note the absence of remarks about the extent of involved skin, since our results suggest
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