Soluble HLA-I-mediated secretion of TGF-β1 by human NK cells and consequent down-regulation of anti-tumor cytolytic activity

Thrombin down-regulates the TGF-β-mediat

Thrombin down-regulates the TGF-β-mediated synthesis of collagen and fibronectin by human proximal tubule epithelial cells through the EPCR-dependent activation of PAR-1

✍ Jong-Sup Bae; In-San Kim; Alireza R. Rezaie 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 148 KB

## Abstract Human proximal tubule (HK‐2) cells are commonly used as cellular models to understand the mechanism by which inflammatory mediators cause renal injury. It has been observed that thrombin stimulates the expression of TGF‐β, extracellular matrix (ECM) proteins and proinflammatory cytokine