Soluble glucocorticoid-induced tumor necrosis factor receptor (sGITR) increased MMP-9 activity in murine macrophage

✍ Scribed by Hee-Sook Lee; Hyun-Hee Shin; Byoung S. Kwon; Hye-Seon Choi

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 170 KB
• Volume: 88
• Category: Article
• ISSN: 0730-2312
• DOI: 10.1002/jcb.10456

✦ Synopsis

Abstract

Glucocorticoid induced tumor necrosis factor receptor (GITR), a new TNFR family, increased production of matrix matalloproteinase (MMP‐9) in murine macrophages. Murine macrophages produced a band of gelatinolytic activity at 100 kDa when stimulated for 18 h with soluble GITR. MMP‐9 was identified by gelatin zymography and Western blot. Previous results demonstrated that murine macrophages express GITR and GITR ligand constitutively. Induction of MMP‐9 was synergistic with co‐treatment of INF‐γ. MMPs could play a critical role in progression and promotion of tissue injury after inflammation stimulated by GITR/ligand system. J. Cell. Biochem. 88: 1048–1056, 2003. © 2003 Wiley‐Liss, Inc.