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Soluble epoxide hydrolase variant (Glu287Arg) modifies plasma total cholesterol and triglyceride phenotype in familial hypercholesterolemia: intrafamilial association study in an eight-generation hyperlipidemic kindred

✍ Scribed by Keiko Sato; Mitsuru Emi; Yoichi Ezura; Yuko Fujita; Daisuke Takada; Tomoaki Ishigami; Satoshi Umemura; Yunpei Xin; LilyL. Wu; Stacey Larrinaga-Shum; SusanH. Stephenson; StevenC. Hunt; PaulN. Hopkins


Book ID
106251755
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
231 KB
Volume
49
Category
Article
ISSN
1435-232X

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## Abstract Defect of growth hormone receptor (GHR) is classically known to cause Laron syndrome, characterized by short stature, specific facial appearance, elevated serum growth hormone levels, and decreased insulin‐like growth factor I levels. In addition, an increased cardiovascular risk due to