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Soluble domains of telomerase reverse transcriptase identified by high-throughput screening

โœ Scribed by Steven A. Jacobs; Elaine R. Podell; Deborah S. Wuttke; Thomas R. Cech


Book ID
119824598
Publisher
Cold Spring Harbor Laboratory Press
Year
2005
Tongue
English
Weight
911 KB
Volume
14
Category
Article
ISSN
0961-8368

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## Abstract Highโ€throughput smallโ€molecule screens hold great promise for identifying compounds with potential therapeutic value in the treatment of proteinโ€trafficking diseases such as cystic fibrosis (CF) and nephrogenic diabetes insipidus (NDI). The approach usually involves expressing the mutan