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Soluble CD44 variants in serum of patients with prostate cancer and other urological malignancies

✍ Scribed by Lein, Michael; Weiβ, Susanne; Jung, Klaus; Schnorr, Dietmar; Loening, Stefan

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
126 KB
Volume
29
Category
Article
ISSN
0270-4137

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✦ Synopsis

In a recent paper published in this journal [l], the authors measured the expression of CD44 isoforms in four human prostate tumor cell lines by flow cytometric analysis, Western blot, and at the mRNA level by reverse transcription polymerase chain reaction. The results showed that CD44 isoforms were expressed in human prostate tumor cell lines, including the expression of variant isoforms containing the v6 region. The authors found altered expressions of CD44 in human prostatic adenocarcinomas and suggest further intensive research in this direction. In addition to studies in tissue, the determination of soluble CD44 fragments in body fluids has been suggested as a promising non-invasive method to assess tumor burden and metastases in patients with malignant diseases [2]. We will shortly report data collected in this respect in patients suffering urological malig-

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