Soluble CD25 in serum: a potential marker for subclinical macrophage activation syndrome in patients with active systemic onset juvenile idiopathic arthritis
β Scribed by Reddy, Vishnu V.; Myles, Arpita; Cheekatla, Satyanaryan S.; Singh, Sushma; Aggarwal, Amita
- Book ID
- 121761987
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2014
- Tongue
- English
- Weight
- 130 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1756-1841
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## Abstract ## Objective Macrophage activation syndrome is characterized by an overwhelming inflammatory reaction driven by excessive expansion of T cells and hemophagocytic macrophages. Levels of soluble interleukinβ2 receptor Ξ± (sILβ2RΞ±) and soluble CD163 (sCD163) may reflect the degree of activ
## Abstract The aberrant induction of proinflammatory cytokines is considered to be crucial in the pathogenesis of systemic juvenile idiopathic arthritis and adultβonset Still's disease. Interleukinβ18 (ILβ18) in particular has been reported to be a candidate for the key cytokine in both diseases;