Solubilization of aromatics in aqueous bile salts. IV—Two-dimensional 1H NMR study on intra- and inter-molecular interactions in aromatic solubilizate–cholate systems
✍ Scribed by E. Kolehmainen
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 390 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0749-1581
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✦ Synopsis
Solubilization of aromatics in aqueous bile
salts was studied by two-dimensional (2D) nuclear Overhauser enhancement spectroscopy (NOESY) for three model systems: benzene, anisole and veratrole solubilized in aqueous sodium cholate. The observed intra-and inter-molecular cross-relaxation properties are discussed in terms of different solubilization sites available for different solubilizates. The cholate anions located in the micelles seem to maintain their intramolecular cross-relaxation characteristics during the mixed micelle formation. A molecular mechanical calculation of the cholate anion was performed in order to determine the non-bonded internuclear distances between the NOE-connected nuclei.