## Abstract A meanโfield model for charged dendrimers has been elaborated and applied to Astramol dendrimers of 5^th^ generation in saltโfree solution. The free energy of a dendrimer molecule was minimized with respect to the dendrimer size and to the profile of counterion distribution. The model o
Solubilization and Release Properties of PEGylated Diaminobutane Poly(propylene imine) Dendrimers
โ Scribed by Zili Sideratou; Dimitris Tsiourvas; Constantinos M. Paleos
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 63 KB
- Volume
- 242
- Category
- Article
- ISSN
- 0021-9797
No coin nor oath required. For personal study only.
โฆ Synopsis
PEGylated diaminobutane poly(propylene imine) dendrimers were investigated as prospective drug delivery systems. Solubilization and release properties of these dendrimeric derivatives were investigated by fluorescence spectroscopy by employing pyrene as probe. The prospective application of the same dendrimers as drug carriers was first evaluated by incorporating within their interior sufficient concentrations of betamethasone corticosteroids.
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## Abstract **Summary:** Polypeptideโshelled poly(propylene imine) dendrimers were realized by ringโopening polymerization of __ฮฑ__โamino acid __N__โcarboxyanhydrides, initiated by dendrimers as core molecules. Polypeptides with 2nd generation core were used as model compounds to investigate interi
The highly branched, three-dimensional geometry of dendritic macromolecules [1] makes these new molecular architec-tures ideal container molecules. [2] It has been suggested that these molecules could be used in a number of applications including those related to the controlled release of pharmaceut