Dissolution of ionizable water-insoluble
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Junichi Jinno; Doo-man Oh; John R. Crison; Gordon L. Amidon
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Article
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2000
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John Wiley and Sons
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English
β 251 KB
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This study reports the results of the combined effect of pH and surfactant on the dissolution of piroxicam (PX), an ionizable water-insoluble drug in physiological pH. The intrinsic dissolution rate (J total ) of PX was measured in the pH range from 4.0 to 7.8 with 0%, 0.5%, and 2.0% sodium lauryl s