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Solubilization and dissolution of insoluble weak acid, ketoprofen: Effects of pH combined with surfactant

✍ Scribed by Jennifer J. Sheng; Nehal A. Kasim; Ramachandran Chandrasekharan; Gordon L. Amidon


Book ID
113591680
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
590 KB
Volume
29
Category
Article
ISSN
0928-0987

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This study reports the results of the combined effect of pH and surfactant on the dissolution of piroxicam (PX), an ionizable water-insoluble drug in physiological pH. The intrinsic dissolution rate (J total ) of PX was measured in the pH range from 4.0 to 7.8 with 0%, 0.5%, and 2.0% sodium lauryl s