Solubility or some steroids in water

✍ Scribed by Peter Kabasakalian; Eli Britt; Milton D. Yudis

• Book ID: 102401247
• Publisher: John Wiley and Sons
• Year: 1966
• Tongue: English
• Weight: 115 KB
• Volume: 55
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600550625

✦ Synopsis

The solubility of 2 1 steroids in water at 2 5 was determined and compared with previous data whenever available.

CATTERED data have been reported in the lit-S erature for the solubility of a number of steroids (1-8) in water. Howcver, there seems to be no single collection of such information nor is there sufficient data, particularly for the C1-dehydro corticosteroids, which have gained widespread use in pharmaccutical and medical practice during the past 10 years. A greater need for this kind of inforination stems from the increased interest in the depcndcncc of drug activity upon solution concentration, which in turn is often related to drug solubility in water. 11 furthcr application for such data is useful in the dcsign of dissolution rate studies.

It is believed, thcrefore, that the water solubility of a nuinber of steroids in clinical use should be reported.