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Solubility of the antibiotic Penicillin G in supercritical carbon dioxide

✍ Scribed by M.D Gordillo; M.A Blanco; A Molero; E Martinez de la Ossa

Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
238 KB
Volume
15
Category
Article
ISSN
0896-8446

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✦ Synopsis

The solubility of the antibiotic Penicillin G in supercritical carbon dioxide was measured at pressures from 100 to 350 bar and temperatures from 313.15 to 333.15 K using a dynamic flow apparatus. Physical properties and critical parameters of Penicillin G were estimated using Fedor's and Ambrose's group contribution methods. The experimental data were correlated using the Redlich-Kwong and Soave-Redlich-Kwong equations of state, with Lorent-Berthelot mixing rules. A second order empirical model to correlate solubility directly with temperature and pressure was used.

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