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Solubility of nonelectrolytes in polar solvents. VI. Refinements in molecular surface area computations

โœ Scribed by Valvani, S. C.; Yalkowsky, S. H.; Amidon, G. L.

Book ID
121863235
Publisher
American Chemical Society
Year
1976
Tongue
English
Weight
853 KB
Volume
80
Category
Article
ISSN
0022-3654

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๐Ÿ“œ SIMILAR VOLUMES

Solubility of nonelectrolytes in polar s
Solubility of nonelectrolytes in polar solvents IV: Nonpolar drugs in mixed solvents
โœ S. H. Yalkowsky; S. C. Valvani; G. L. Amidon ๐Ÿ“‚ Article ๐Ÿ“… 1976 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 758 KB

The molecular and group surface area approach to solubility is shown to be applicable to mixed aqueous solvent systems. An equation is derived which is consistent with the exponential increase in the aqueous solubility of nonpolar drugs that frequently accompanies the addition of a cosolvent. This e