Solubility in Pharmaceutical Chemistry

✍ Scribed by Christoph Saal (editor); Anita Nair (editor)

• Publisher: De Gruyter
• Year: 2020
• Tongue: English
• Leaves: 370
• Category: Library

✦ Synopsis

This book describes the physicochemical fundamentals and biomedical principles of drug solubility. Methods to study and predict solubility in silico and in vitro are described and the role of solubility in a medicinal chemistry and pharmaceutical industry context are discussed. Approaches to modify and control solubility of a drug during the manufacturing process and of the pharmaceutical product are essential practical aspects of this book.

Includes crucial physicochemical fundamentals, basic principles and methods to study solubility of drugs. Biomedical, chemical and manufacturing aspects are described in the context of medicinal chemistry as well as pharmaceutical industry.

✦ Table of Contents

Contents
List of contributors
1. Solubility – definition and basic physicochemical considerations
2. Solubility and supersaturation
3. In Silico methods to predict solubility
4. How solubility influences bioavailability
5. Estimation of intraluminal drug solubility
6. Biorelevant media
7. The role of solubility to optimize drug substances – a medicinal chemistry perspective
8. The role of solubility in optimizing drug products – a pharmaceutical development perspective
9. The relevance of solid-state forms for solubility
10. Solubility and phase behaviour from a drug substance manufacturing perspective
11. Biowaivers
List of Abbreviations
Index