Solubility-Driven Optimization of Phosphodiesterase-4 Inhibitors Leading to a Clinical Candidate

✍ Scribed by Press, Neil J.; Taylor, Roger J.; Fullerton, Joseph D.; Tranter, Pamela; McCarthy, Clive; Keller, Thomas H.; Arnold, Nicola; Beer, David; Brown, Lyndon; Cheung, Robert; Christie, Julie; Denholm, Alastair; Haberthuer, Sandra; Hatto, Julia D. I.; Keenan, Mark; Mercer, Mark K.; Oakman, Helen; Sahri, Helene; Tuffnell, Andrew R.; Tweed, Morris; Tyler, John W.; Wagner, Trixie; Fozard, John R.; Trifilieff, Alexandre

• Book ID: 115500463
• Publisher: American Chemical Society
• Year: 2012
• Tongue: English
• Weight: 646 KB
• Volume: 55
• Category: Article
• ISSN: 0022-2623
• DOI: 10.1021/jm300459a