Solubility and hydrogen-ion concentration of quinine salts.**Scientific Section, A. Ph. A., New York meeting, 1937.

✍ Scribed by Johnson, Frederick F.

• Publisher: Elsevier
• Year: 1937
• Weight: 293 KB
• Volume: 26
• Category: Article
• ISSN: 0898-140X
• DOI: 10.1002/jps.3080261204

✦ Synopsis

This work was undertaken with the hope of obtaining more fundamental information concerning the dissociation of free acid from an alkaloidal salt. The principles shown and verified in this paper will be used in an attempt to prepare a series of more soluble and less acid quinine salts.

Since there were no data in the literature concerning the change in acidity of quinine dihydrochloride during sterilization and storage, it was decided to observe these changes while the work was in progress. Solutions were prepared of strengths equivalent to those commonly used for injection purposes, namely, 3.25%, lo%,