Solitary mast cell granuloma (histiocytoma) of the lung. A Histopathologic, Tissue Culture and Time-Lapse Cinematographic Study
✍ Scribed by Russell P. Sherwin; William H. Kern; John C. Jones
- Publisher
- John Wiley and Sons
- Year
- 1965
- Tongue
- English
- Weight
- 907 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
T variety of nonspecific granulomas of the lung is the presence of a histiocytic infiltrate within all of the lesions. However, there is a considerable variation in the type of histiocyte present (i.e. epithelioid cell varieties, foam cells, giant cells and macrophages) and there are unique variations in the nature of the associated tissue changes. Some of the more prominent associated factors have been used to support a presumable granuloma spectrum for pulmonary histiocytoma, in particular, the participation of eosinophils (eosinophilic granuloma)2,21 and plasma cells (plasmacytoma),sp 15 vascular proliferation (sclerosing hemangioma),ls fibrocystic change ("honeycomb lung"),lo and similar lesions elsewhere in the body (Histiocytosis X).3, I n view of the uncertainty as to the basic nature of the disease or diseases, a part of the fresh tissue from a single case of pulmonary histiocytoma was subjected to a tissue culture study. T h e particular goals sought were clarification of the type of tissues participating and insight into the possible neoplastic relationship of the disease process. Of great interest was the presence of innumerable mast cells and a moderate number of plasma cells; eosinophils were absent. Time-lapse cinematographic records of the mast cells were obtained utilizing primary explants in Rose chambers. T h e records were compared with studies of mast cell behavior reported in other