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Solid Tumours Show Osteotropism: Mechanisms of Bone Metastases

✍ Scribed by Roato, Ilaria; Ferracini, Riccardo

Book ID
121343591
Publisher
Springer-Verlag
Year
2013
Tongue
English
Weight
265 KB
Volume
11
Category
Article
ISSN
1534-8644

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## BACKGROUND. Breast carcinoma commonly metastasizes to the skeleton in patients with advanced disease to cause bone destruction and the associated pain, hypercalcemia, fracture, and nerve-compression syndromes. In this scenario, the bone destruction is mediated by the osteoclast. Tumor-produced