Solid tumors of children: Chromosome abnormalities and the development of cancer

✍ Scribed by Fred Gilbert

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 559 KB
• Volume: 121
• Category: Article
• ISSN: 0021-9541
• DOI: 10.1002/jcp.1041210419

✦ Synopsis

Chromosome abnormalities in five solid tumors which occur predominantly in children and young adults are described. Four of the tumors are associated with rearrangements involving particular chromosome segments: deletion 13q14 in retinoblastoma, deletion 1 1 ~1 3 in Wilms' tumor, deletionslrearrangements of 1p (distal to band lp31) in neuroblastoma, and translocation 22/ autosome in Ewing sarcoma. Though aneuploidy for a number of chromosomes may occur in the fifth tumor, rhabdomyosarcoma, it has yet to be associated with a consistent marker arrangement. A general classification of chromosome abnormalities in cancer is presented. Possible roles for the gene changes produced by each class of chromosome abnormality in the development of cancer are discussed.

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