Accelerating proof of concept for small
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Stephen R. Byrn; George Zografi; Xiaoming (Sean) Chen
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Article
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2010
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John Wiley and Sons
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English
β 304 KB
In this perspective we have shown that the process of ''proof of concept'' (POC) in the early part of drug development can be greatly accelerated by close attention to the underlying solid-state chemistry (SSC) of a new chemical entity. POC seeks data that provide confidence in the therapeutic activ